Matrine Inhibits Breast Cancer Growth Via<b><i>miR-21/PTEN/Akt</i></b>Pathway in MCF-7 Cells

Abstract

Our study unraveled, for the first time, the ability of matrine to suppress breast cancer growth and elucidated the miR-21/PTEN/Akt pathway as a signaling mechanism for the anti-cancer action of matrine. Our findings also reinforce the notion that miRNAs can act as mediators of the therapeutic efficacy of natural medicines.