Association of Primary Breast Cancer of the Vulva With Hereditary Breast and Ovarian Cancer

Abstract

A 59-year-old woman of French-Canadian ancestry, with a family history of breast cancer and a documented BRCA2 mutation in a first-degree relative, sought care for a 5-month history of a 1-cm, raised, and erythematous mass lateral to the left labium majus. Excisional biopsy results revealed infiltrating mammary adenocarcinoma with mucinous differentiation (Fig The tumor cells were positive for cytokeratin 7 (CK7), mammoglobin (Fig 1B), estrogen receptor (90%; Fig 1C), and progesterone receptor (30%), and were negative for CK20, Wilms tumor 1, gross cystic disease fluid protein 15, and human epidermal growth factor receptor 2 (HER2)/neu (1). The tumor infiltrated through the epithelium, and specimen biopsy margins were focally positive.