Organic & Biomolecular Chemistry · 2007 · 35 citations · 20 references
Pharmaceutical ChemistryEngineeringHeterocyclicMedicineP53-hdm2 Interaction InhibitorsMicrowave-assisted Liebeskind-srogl ReactionOrganic ChemistryAnti-cancer AgentChemistryHeterocycle ChemistryPharmacologyNew AnaloguesEfficient C2 FunctionalisationBiomolecular EngineeringDrug Discovery
Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).
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