Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E ₂ Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms

Abstract

COX-2/mPGES-1 are expressed in the wall of human cerebral aneurysms and more abundantly so in ruptured aneurysms than in nonruptured. We speculate that the protective effect of aspirin against rupture of cerebral aneurysms may be mediated in part by inhibition of COX-2/mPGES-1.