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In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria

Kevin M. Krause, Marika Renelli, Stacey Difuntorum, Terry X. Wu, Dmitri Debabov, Bret M. Benton

Antimicrobial Agents and Chemotherapy · 2008 · 97 citations · 6 references

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Abstract

The in vitro activity of telavancin was tested against 743 predominantly antimicrobial-resistant, gram-positive isolates. Telavancin was highly active against methicillin-resistant staphylococci (MIC(90), 0.5 to 1 microg/ml), streptococci (all MICs, < or =0.12 microg/ml), and VanB-type enterococci (all MICs, < or =2 microg/ml). Time-kill studies demonstrated the potent bactericidal activity of telavancin.

References

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Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically

Mary Jane Ferraro · 2000 · 16.9K citations

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Comparative activity of the new lipoglycopeptide telavancin in the presence and absence of serum against 50 glycopeptide non-susceptible staphylococci and three vancomycin-resistant Staphylococcus aureus

Kimberly Leuthner · Journal of Antimicrobial Chemotherapy · 2006 · 123 citations · Full text

Comparative in vitro activity of telavancin (TD-6424), a rapidly bactericidal, concentration-dependent anti-infective with multiple mechanisms of action against Gram-positive bacteria

Anna King · Journal of Antimicrobial Chemotherapy · 2004 · 114 citations · Full text

In Vitro Activity of TD-6424 against<i>Staphylococcus aureus</i>

John Pace, Kevin M. Krause, Deborah Johnston et al. · Antimicrobial Agents and Chemotherapy · 2003 · 108 citations · Full text

In Vitro Activities of the New Semisynthetic Glycopeptide Telavancin (TD-6424), Vancomycin, Daptomycin, Linezolid, and Four Comparator Agents against Anaerobic Gram-Positive Species and <i>Corynebacterium</i> spp

Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam et al. · Antimicrobial Agents and Chemotherapy · 2004 · 107 citations · Full text