Inhibition of VE-Cadherin Proteasomal Degradation Attenuates Microvascular Hyperpermeability

Abstract

VE-cadherin disruption in animals results in hyperpermeability. Parallel studies in RLMEC demonstrated similar results. In addition, inhibition of proteasomal degradation attenuated microvascular hyperpermeability. These findings have significance in understanding the role of VE-cadherin in regulating vascular hyperpermeability.