Radiology · 1980 · 76 citations · 0 references
MedicineCancer BiologyOncologyHeat TransferHeatingTumor PathologyHeat InjuryHeat StressHeat Stress PhysiologyTemperature ManagementTemperature RegulationThermal PhysiologyBlood FlowCapillary Blood FlowCapillary FlowHeat Transfer In TissuesHistopathological ResponseHyperthermiaTemperature Effects On Vascular FunctionVascular Response To Thermal Stimuli
Specific capillary blood flow and small-vessel pathology in animal tumors (rhabdomyosarcoma BA-1112) of WAG/Rij rats were examined following local tumor heating to 40-44.5 degrees C. Blood flow in tumors heated to 40-41 degrees C for 40 minutes was reduced initially by about 50%, but returned to near preheating values within 72 hours, consistent with the histopathological observations indicating small-vessel dilation and temporary congestion. The application of hyperthermia greater than 43 degrees C (for 40 minutes) resulted in the virtual elimination of capillary blood flow, consistent with pathological findings of widespread vessel rupture and hemorrhage in this temperature range.