Integrated Genomic Profiling, Therapy Response, and Survival in Adult Acute Myelogenous Leukemia

Abstract

Integrated genomic profiling of a clinically relevant adult AML cohort identified genomic aberrations most associated with SNP-A-based genomic complexity, resistance to intensive induction therapies, and shortened overall survival. Identifying SNP-A-based lesions adds prognostic value to the status of several recurrently mutated genes.