Isolation of a transplantable cell line induced by the MC29 avian leukosis virus.

Abstract

Summary A transplantable cell line was isolated from a liver tumor induced by the MC29 strain of avian leukosis virus. It was found that its ability to develop into a tumor when inoculated in recipient birds (both intramuscularly and in the wing web) was dependent on a morphological alteration which took place after the cells had been in culture for some time. The transplantable cell exhibited unusual properties, compared with other MC29 altered cells, and appears to represent a unique target cell for the MC29 virus.