Four Missense Mutations in the Ghrelin Receptor Result in Distinct Pharmacological Abnormalities

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

Christian Vaisse, Karine Clément, Emmanuelle Durand et al. · Journal of Clinical Investigation · 2000 · 900 citations · Full text

Life Sciences, Endocrinology, Molecular Genetics +13

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

Yuxiang Sun, Pei Wang, Hui Zheng et al. · Proceedings of the National Academy of Sciences · 2004 · 748 citations · Full text

Life Sciences, Endocrinology, Pharmacology +17

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Jeffrey M. Zigman · Journal of Clinical Investigation · 2005 · 642 citations · Full text

Life Sciences, Endocrinology, Physiology +17

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Jean-Pierre Morello, Ali Salahpour, André Laperrière et al. · Journal of Clinical Investigation · 2000 · 562 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

High Constitutive Signaling of the Ghrelin Receptor—Identification of a Potent Inverse Agonist

Birgitte Holst, Adam I. Cygankiewicz, Tine H. Jensen et al. · Molecular Endocrinology · 2003 · 516 citations

Life Sciences, Endocrinology, Physiology +17