In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self‐Assembled Silica Beads in Filopodium‐Size Ranges

Abstract

Something to sprout about: The developmental acceleration of hippocampal neurons occurred on well-packed structures of silica beads with diameters over 200 nm (see picture; scale bar: 5 μm, inset scale bar: 1 μm). The neurons sensed the size differences of the nanostructures and altered their behaviors, thus implying that nanotopographical stimuli are one of the important features for guiding neurites during neural developments in vivo. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.