Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Timothy M. Frayling, Nicholas J. Timpson, Michael N. Weedon et al. · Science · 2007 · 4.4K citations · Full text

A Map of Recent Positive Selection in the Human Genome

Benjamin F. Voight, Sridhar Kudaravalli, Xiaoquan Wen et al. · PLoS Biology · 2006 · 3K citations · Full text

Single Nucleotide Polymorphism, Genetics, Genomics +21

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

James V. Neel · PubMed · 1999 · 2.5K citations · Full text

Genetics, Genetic Epidemiology, Population Ceneticist +17

Detecting recent positive selection in the human genome from haplotype structure

Pardis C. Sabeti, David Reich, John M. Higgins et al. · Nature · 2002 · 2.2K citations

Genetic Analysis, Allelic Variant, Haplotype Determination +13

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Nature Genetics · 2008 · 1.3K citations · Full text

Obesity, Metabolic Syndrome, Metabolic Disorder +7