XRCC3 Polymorphisms are Associated with the Risk of Developing Radiation-induced Late Xerostomia in Nasopharyngeal Carcinoma Patients Treated with Intensity Modulation Radiated Therapy

Abstract

To our knowledge, this is the first study that demonstrated an association between genetic polymorphisms and the risk of radiation-induced late xerostomia in nasopharyngeal carcinoma patients treated with Intensity Modulation Radiated Therapy. Our findings suggest that the polymorphisms in XRCC3 are significantly associated with the risk of developing radiation-induced late xerostomia.