Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells

Abstract

Rab5a and Rab7a regulate VEGFR2 trafficking toward early and late endosomes. Our data suggest that VEGFR2-mediated regulation of endothelial function is dependent on different but specific Rab-mediated GTP hydrolysis activity required for endosomal trafficking.