Synthesis of (+)-malyngolide from (+)-tartaric acid

Abstract

(+)-Malyngolide (+)-(1), the antipode of natural malyngolide, was synthesized in 9 steps from dimethyl (2R,3R)-(–)-tartrate acetonide (3)via(2R)-(–)-2-nonylbutane-1,2,4-triol (8) in 5.1 % overall yield.