Characterizing the Effects of Caspofungin on <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments

Abstract

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.