Oxidative coupling of thiols to disulfides in solution and under microwave radiation with tripropylammonium chlorochromate

Abstract

A mild and efficient method for the oxidative coupling of thiols by tripropylammonium chlorochromate in solution and in solution under microwave radiation is reported. Tripropylammonium chlorochromate is an efficient and new reagent, is easily prepared, and rapidly oxidizes thiols to the corresponding disulfides. The reactions proceed cleanly and stop at the disulfide stage without over-oxidation to side-products. The simple procedure and work-up, short reaction times, and excellent yields are all advantages of this reagent.