Infection and Immunity · 2003 · 126 citations · 22 references
Veterinary MedicineImmunologyInfectious DiseasesHost-pathogen InteractionsImmunology Of Infectious DiseasesImmunoregulationCytokine BiologyGranulomatous InflammationHost-parasite Immune InteractionsImmunopathology Of Parasitic DiseaseImmunoregulation In Parasitic InfectionParasitic Disease PathogenesisGranuloma Formation In Parasitic DiseaseGranulomatous Response To ParasitesImmunopathology Of LeishmaniasisInnate Cytokine ResponsesLeishmaniasis PathogenesisLeishmaniasis PathologyLeishmaniasis-associated GranulomasParasitic Granulomatous Inflammation
The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.
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Mónica G. Chiaramonte, Debra D. Donaldson, Allen W. Cheever et al. · Journal of Clinical Investigation · 1999 · 599 citations · Full text