Contributions of endothelin‐1 and sodium hydrogen exchanger‐1 in the diabetic myocardium

Abstract

These results indicate an important contribution of both ET-1 and NHE-1 in the pathogenesis of diabetic cardiomyopathy. These data suggest that NHE-1 may act as a downstream mediator in the production of ET-induced functional and structural changes in the myocardium in diabetes.