Suppression of Gene Expression by G‐Quadruplexes in Open Reading Frames Depends on G‐Quadruplex Stability

Abstract

Suppressing the urge to translate: Sequences with the potential to form G-quadruplexes were identified in the open reading frames of E. coli genes. These sequences were found to form parallel G-quadruplexes and to suppress translation (see picture) of the mRNAs into proteins both in vitro and in cells.