The MUC1 mucin protects against <i>Helicobacter pylori</i> pathogenesis in mice by regulation of the NLRP3 inflammasome

Abstract

MUC1 is an important, previously unidentified negative regulator of the NLRP3 inflammasome. H. pylori activation of the NLRP3 inflammasome is normally tightly regulated by MUC1, and loss of this critical regulation results in the development of severe pathology.