Combination therapy of poly (ADP‐ribose) polymerase inhibitor 3‐aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells

Abstract

This in vivo study demonstrated a significantly reduced tumor weight and increased survival up to 40 days after cell inoculation with combination therapy compared to animals treated with PBS, gemcitabine or 3-ABA alone. Furthermore, TUNEL assay revealed a significant apoptosis induction and reduced proliferation in the combination group.