On the Antimicrobial and Hemolytic Activities of Amphiphilic <i>β</i> ‐Peptides

Abstract

Not generally harmful: The antimicrobial and hemolytic activity of amphiphilic β-homo (β-H) peptides with the general formula H-(β-HAla-β-HLys-β-HPhe)-OH (see schematic representation) were investigated to unravel their potential for applications in medicinal chemistry. Only moderate activities were found for some of the peptides tested, critically depending on the side-chain composition of the amphiphilic helix.