Targeting Matrilysin and Its Impact on Tumor Growth <i>In vivo</i>: The Potential Implications in Breast Cancer Therapy

Abstract

Matrilysin, which is aberrantly expressed in human breast tumors, can be effectively eliminated from breast cancer cells by way of hammerhead ribozyme transgene. Elimination of matrilysin is associated with low invasiveness and slow tumor growth. Taken together, the study suggests that targeting matrilysin may have important therapeutic implications.