The endocytosis and intracellular fate of nanomedicines: Implication for rational design

TLDR

Nanomedicines use multiple endocytic pathways to enter cells, yet their subsequent intracellular fate remains insufficiently understood. The review aims to introduce endocytic pathways, present new technologies for confirming specific pathways, discuss factors influencing pathway selection, and explore implications for nanomedicine design. It employs new technologies to confirm specific endocytic pathways and examines factors that determine pathway choice. The review offers new insights that may guide the design of multifunctional nanomedicines.

Abstract

Nanomedicines employ multiple endocytic pathways to enter cells. Their following fate is interesting, but it is not sufficient understood currently. This review introduces the endocytic pathways, presents new technologies to confirm the specific endocytic pathways and discusses factors for pathway selection. In addition, some intriguing implication about nanomedicine design based on endocytosis will also be discussed at the end. This review may provide new thoughts for the design of novel multifunctional nanomedicines.