Synthesis and antibacterial activity of new 2-aryloxy-6-bromo-3-(4-chlorophenyl)-3,4-dihydrobenzo[e][1,3,2]oxazaphosphinine2-oxides

Abstract

oxazaphosphinine 2-oxides 3 have been synthesized by the reaction of 4-bromo-2-[(4-chlorophenylamino)methyl]phenol (1) with various aryl phosphorodichloridates 2a-i in the presence of triethylamine in dry toluenetetrahydrofuran at 45-50 C. Products 3 were characterized by IR, 1 H, 13 C, and 31 P NMR spectra, and their antibacterial activity was evaluated.