Large Protein Assemblies Formed by Multivalent Interactions between Cadherin23 and Harmonin Suggest a Stable Anchorage Structure at the Tip Link of Stereocilia

Abstract

Background: How the root of stereocilia tip link is designed to withstand mechanical stretching is poorly understood. Results: Cadherin23 tail and harmonin form polymeric protein assemblies via nonsynergistic, multisite interactions.