Comparison of the renal excretion of Hypaque 45% and Urografin 60%

Abstract

The renal excretion of Hypaque 45% and Urografin 60% in doses containing equal amounts of diatrizoate was compared ten times in six subjects. The doses ranged from 0·25 to 0·75 ml./lb. Hypaque 45% or the equivalent amount of Urografin 60%. In every study the urinary concentration of diatrizoate was higher after Hypaque 45% (the pure sodium salt) than after Urografin 60% (predominantly the methylglucamine salt). The diuresis was always greater with Urografin 60%. The pattern of excretion of diatrizoate was the same with both compounds.