Chronic Alcohol Consumption During Male Rat Adolescence Impairs Skeletal Development Through Effects on Osteoblast Gene Expression, Bone Mineral Density, and Bone Strength

Abstract

Chronic consumption of EtOH during the peripubertal period of skeletal growth leads directly to decreased metaphyseal and cortical bone mediated through effects on osteoblasts. Removal of EtOH from the diet is accompanied by incomplete restoration of normal bone metabolism during skeletal growth.