Electrocatalytic Oxidation of Acyclovir on Poly(<i>p</i>‐Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode

Abstract

Abstract Acyclovir is an antiviral effective drug active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p ‐aminobenzene sulfonic acid ( p‐ ABSA) in phosphate buffer solution (PBS). The polymer film‐modified electrode was used to electrochemically detect acyclovir. Polymer film showed excellent electrocatalytic activity for the oxidation of acyclovir. The anodic peak potential value of the acyclovir at the poly( p ‐ABSA) modified glassy carbon electrode was 950 mV obtained by DPV. A linear calibration curve for DPV analysis was constructed in the acyclovir concentration range 2×10 −7 –9×10 −6 mol L −1 . Limit of detection ( LOD ) and limit of quantification ( LOQ ) were obtained as 5.57×10 −8 and 1.85×10 −7 mol L −1 respectively. The proposed method exhibits good recovery and reproducibility.