Decreased Striatal Dopamine D₁ Receptor- Stimulated Adenylyl Cyclase Activity in Human Methamphetamine Users

Abstract

These data suggest that dopamine receptor function linked to adenylyl cyclase is partially desensitized in the striatum of human methamphetamine users. Decreased dopamine D(1) receptor function might underlie part of the known (drug withdrawal syndrome) or expected (drug tolerance) consequences of methamphetamine exposure in humans.