Proceedings of the National Academy of Sciences · 2010 · 548 citations · 39 references
Life SciencesNeurobiologyNeuroscienceExercise PhysiologyPhysical ActivitySynaptic PlasticityActivity-dependent PlasticityAerobic ExerciseHippocampal DevelopmentLocomotor AdaptationsNeural DevelopmentNeurogenesisAdult Hippocampal NeurogenesisHippocampal PhysiologyRodent NeurogenesisRodent Synaptic PlasticityRunnersRunning AdaptationsRunning PhysiologySpatial Discrimination
Regular exercise enhances brain health, synaptic plasticity, and hippocampal neurogenesis, yet the specific mechanisms underlying improved information processing remain unclear. Voluntary running in adult mice improves spatial pattern separation, correlating with increased neurogenesis, whereas aged mice exhibit impaired discrimination and no benefit from running.
Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms of information processing influenced by physical activity are unknown. Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. Improved spatial pattern separation in adult runners was tightly correlated with increased neurogenesis. In contrast, very aged (22 months old) mice had impaired spatial discrimination and low basal cell genesis that was refractory to running. These findings suggest that the addition of newly born neurons may bolster dentate gyrus-mediated encoding of fine spatial distinctions.
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Neurogenesis in the adult human hippocampus
Peter S. Eriksson, Ekaterina Perfilieva, Thomas Björk‐Eriksson et al. · Nature Medicine · 1998 · 6.3K citations