Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP - Concepedia

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Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP

DOI Full Paper Access

77

Citations

39

References

2012

Year

Shaoman Yin, Štefan Kaluz, Narra S. Devi, Adnan Abdul Jabbar, Rita G. de Noronha, Ji-Young Mun, Zhaobin Zhang, Purushotham R. Boreddy, Wei Wang, Zhibo Wang,

Clinical Cancer Research

Abstract

Our results suggest that the new HIF pathway inhibitor KCN1 has antitumor activity in mouse models, supporting its further translation for the treatment of human tumors displaying hypoxia or HIF overexpression.

References

	Year	Citations

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