The Effect of DOPA on the Spinal Cord 5. Reciprocal organization of pathways transmitting excitatory action to alpha motoneurones of flexors and extensors

TLDR

In spinal cats, DOPA is thought to activate a normally inhibited neuronal pathway that mediates long‑latency discharges and reciprocal interneuronal innervation linked to primary afferent depolarization and rhythmic movements. The authors mapped the DOPA‑released pathway by recording efferent discharges to flexors and extensors and intracellular activity in motoneurones. DOPA induces a long‑latency discharge in ipsilateral flexor and contralateral extensor motoneurones, with reciprocal inhibition between ipsilateral and contralateral flexor/ extensor reflex afferents mediated at the interneuronal level.

Abstract

Abstract In unanaesthetized spinal cats, injected with L‐DOPA, volleys in the flexor reflex afferents (FRA) evoke a long‐latency, longlasting discharge in ipsilateral flexor and contralateral extensor motoneurones. It is postulated that this discharge is transmitted by a neuronal pathway which is inhibited in the normal acute spinal cat, presumably from the pathway, which in this state transmits the shortlatency effect from the FRA to motoneurones. The organization of the pathway released by an injection of DOPA has been analyzed by recording the discharges in efferents to flexors and extensors and with intracellular records from motoneurones. Combined stimulation of ipsilateral and contralateral FRA reveals a reciprocal organization in that either flexor or extensor motoneurones are activated. Transmission from the ipsilateral FRA to flexor motoneurones can be inhibited by volleys in the contralateral FRA, and transmissiqn from the contralateral FRA to extensor motoneurones by volleys in the ipsilateral FRA. These inhibitory effects are neither produced postsynaptically in the motoneurones nor presynaptically by depolarization of primary afferents and are hence exerted at an interneuronal level. The organization of reciprocal innervation at an interneuronal level is discussed in relation to the primary afferent depolarization evoked in Ia afferent terminals after DOPA and to rhythmic alternating movements.