Decreased neutrophils and megakaryocytes in anemic mice of genotype <i>W/W^v</i>

Abstract

Abstract The concentration of neutrophils and megakaryocytes was determined in the marrow of anemic mice of genotype W/W v and their normal (+/+) litter mates. In all groups studied, the humerus of W/W v mice contained significantly less neutrophils and megakaryocytes than did normal animals. Blood neutrophil concentration was less in all groups of W/W v mice but in only one group which was the youngest group studied, did this value differ significantly from normal. The blood and marrow neutrophil response to endotoxin was similar in W/W v and “+/+” animals. This suggests that the neutrophilic system of W/W v mice responds to this stimulus in a relatively normal manner, much as their erythroid system responds to hypoxia, and androgens.