Enantioselective H‐Bond‐Directing Approach for Trienamine‐mediated Reactions in Asymmetric Synthesis

Abstract

Right direction: The presented enantioselective strategy for the preparation of diversely functionalized tetrahydroxanthones is based on a trienamine-mediated cycloaddition between 2,4-dieneals and activated chromones. It is possibile to control the stereochemical outcome of such reactions by employing an H-bond-directing aminocatalyst.