The Digoxin-Propafenone Interaction: Characterization of a Mechanism Using Renal Tubular Cell Monolayers

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

Yusuke Tanigawara, Noboru Okamura, Midori Hirai et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 336 citations

Medicine, Cell Biology, Pharmacology +17

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.

Lyle A. Siddoway, Katherine A. Thompson, C B McAllister et al. · Circulation · 1987 · 274 citations

Medicine, Pharmacokinetics, Pharmacology +14

Transepithelial Transport of Drugs by the Multidrug Transporter in Cultured Madin-Darby Canine Kidney Cell Epithelia

Masaru Horio, Khew‐Voon Chin, Stephen J. Currier et al. · Journal of Biological Chemistry · 1989 · 196 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17