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Reactivity-Based One-Pot Synthesis of a Lewis Y Carbohydrate Hapten: A Colon–Rectal Cancer Antigen Determinant
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2002
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Reactivity-based One-pot StrategyLewis YBiochemistryNatural SciencesDiversity-oriented SynthesisGlycobiologyPolysaccharideImmunotherapeuticsStereoselective SynthesisRrv=relative Reactivity ValueMedicineCarbohydrate-protein InteractionBiomolecular EngineeringReactivity-based One-pot Synthesis
The stereospecific synthesis of a tumor-related carbohydrate antigenic hapten, Lewis Y, from three basic building units 1–3 has been achieved by a reactivity-based one-pot strategy. RRV=relative reactivity value.