Gut · 2006 · 41 citations · 35 references
Our observations suggest that the role of IKK2 activation in pancreatic acini is to induce leucocyte infiltration, but at a moderate level of activation it is not sufficient to induce pancreatic damage in mice. The IKK2(CA) induced infiltrations resemble those observed in autoimmune pancreatitis, indicating a role for IKK2/NF-kappaB in this disease. IKK2(CA) in pancreatic acinar cells increases tissue damage of secretagogue induced experimental pancreatitis underlining the proinflammatory role of the IKK/NF-kappaB pathway in this disease.
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High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
Hideaki Hamano, Shigeyuki Kawa, Akira Horiuchi et al. · New England Journal of Medicine · 2001 · 2.7K citations · Full text
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
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