Psychiatric Symptoms Do Not Correlate With Cognitive Decline, Motor Symptoms, or CAG Repeat Length in Huntington's Disease

Abstract

The lack of correlation between disease severity and psychiatric disturbances indicates that psychiatric disorders progress nonlinearly, possibly because of differential degeneration of the striatal-cortical circuits; the possibility that psychiatric disorders are prevalent in certain families with a member who has Huntington's disease is being further investigated. The lack of correlation between CAG length and cognitive and psychiatric variables needs further investigation.