Lipase YS-catalysed acylation of alcohols: a predictive active site model for lipase YS to identify which enantiomer of a primary or a secondary alcohol reacts faster in this acylation

Abstract

Primary alcohols having a hydroxymethyl group at an S chiral centre and secondary alcohols with an R configuration are preferentially acylated to give the corresponding acetates by lipase YS-catalysed acylation in diisopropyl ether; a predictive cubic-spaced active site model for lipase YS is proposed for identifying which enantiomer of a primary or a secondary alcohol reacts faster in this acylation.