Activity of p-Aminobenzaldehyde, 3-Thiosemicarbazone on Vaccinia Virus in the Chick Embryo and in the Mouse

Abstract

Summaryp-Aminobenzaldehyde, 3-thiosemicarbazone (MC2343) caused a significant delay in death and survival of a small percentage of chick embryos and mice infected with vaccinia virus.At the concentrations tested this compound was inactive against the agent of meningopneumonitis, the vole rickettsia (Baker) and swine influenza virus.Preliminary results indicated that the p-acetamido analogue (Myvizone) was also active against vaccinia virus.