Tandem Intramolecular Hydroalkoxylation–Hydroarylation Reactions: Synthesis of Enantiopure Benzofused Cyclic Ethers from the Chiral Pool

Abstract

Progressive cycling! Highly functionalized benzofused oxabicyclo[3.3.1]nonanes are easily obtained from simple aryl-substituted alquinol derivatives by a catalytic tandem sequence involving an hydroalkoxylation reaction followed by a hydroarylation process, shown here.