Image-Guided Po₂ Probe Measurements Correlated with Parametric Images Derived from ¹⁸F-Fluoromisonidazole Small-Animal PET Data in Rats

Abstract

The use of kinetic modeling on a voxelwise basis can identify tumor hypoxia with improved accuracy over simple tumor-to-plasma ratios. An effective means of controlling noise in the trapping rate constant, k(3), without introducing significant bias, is to constrain K(1) equal to k(2) during the fitting process.