Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties

Abstract

Purpose To evaluate the sensitivity of quantitative MRI techniques (T 1 , T 1,Gd , T 2 , continous wave (CW) T 1ρ dispersion, adiabatic T 1ρ , adiabatic T 2ρ , RAFF and inversion‐prepared magnetization transfer (MT)) for assessment of human articular cartilage with varying degrees of natural degeneration. Methods Osteochondral samples (n = 14) were obtained from the tibial plateaus of patients undergoing total knee replacement. MRI of the specimens was performed at 9.4T and the relaxation time maps were evaluated in the cartilage zones. For reference, quantitative histology, OARSI grading and biomechanical measurements were performed and correlated with MRI findings. Results All MRI parameters, except T 1,Gd , showed statistically significant differences in tangential and full‐thickness regions of interest (ROIs) between early and advanced osteoarthritis (OA) groups, as classified by OARSI grading. CW‐T 1ρ showed significant dispersion in all ROIs and featured classical laminar structure of cartilage with spin‐lock powers below 1000 Hz. Adiabatic T 1ρ , T 2ρ , CW‐T 1ρ, MT, and RAFF correlated strongly with OARSI grade and biomechanical parameters. Conclusion MRI parameters were able to differentiate between early and advanced OA. Furthermore, rotating frame methods, namely adiabatic T 1ρ , adiabatic T 2ρ , CW‐T 1ρ , and RAFF, as well as MT experiment correlated strongly with biomechanical parameters and OARSI grade, suggesting high sensitivity of the parameters for cartilage degeneration. Magn Reson Med 74:249–259, 2015. © 2014 Wiley Periodicals, Inc.