Journal of Analytical Toxicology · 2000 · 54 citations · 6 references
PharmacyPharmacologyToxicologyForensic ToxicologyNeurotoxicologySubstance Abuse ToxicologyDrug DispositionDrug Overdose DiagnosisDrug ToxicityMonoamine NeurochemistryPostmortem Drug AnalysisStimulant ToxicologyAmphetamine DerivativesFemoral Blood AnalysisForensic Stimulant ToxicologyMdma ToxicityMethamphetamine ToxicityOrgan Drug Concentration AnalysisPostmortem Blood AnalysisPostmortem Blood Collection
There has been much publicity in the United Kingdom regarding a new phenylethylamine-based compound called 4-methylthioamphetamine (4-MTA), also known as para-methylthioamphetamine (p-MTA), MTA or "Flatliner". Chemically, 4-MTA is an amphetamine derivative and is a non-neurotoxic potent serotonin-releasing agent and reversible inhibitor of rat monoamine oxidase-A. Analysis of postmortem blood and urine specimens in a case implicating 3,4-methylenedioxymethamphetamine revealed the presence of 4-MTA at a concentration of 4.6 mg/L in femoral blood and 87.2 mg/l in the urine. The concentration of 4-MTA in perimortem blood was measured at 4.2 mg/L. This is the first reported case of death involving 4-MTA in the United Kingdom and the first case known to involve 4-MTA only.
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Disposition of Toxic Drugs and Chemicals in Man
Yale H. Caplan · Journal of Analytical Toxicology · 2015 · 273 citations