Clinical Improvement With Fluoxetine Therapy and Noradrenergic Function in Patients With Panic Disorder

Abstract

Further evidence is provided for the hypothesis of NA dysregulation in PD as reflected by elevations of within-subjects plasma MHPG volatility during clonidine challenge. Effective selective serotonin reuptake inhibitor-antipanic treatment in this clinical sample was paralleled by normalization of dysregulated NA function.