Characterization of the <i>Vibrio cholerae vceCAB</i> Multiple-Drug Resistance Efflux Operon in <i>Escherichia coli</i>

Abstract

Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.