Australian Journal of Chemistry · 2000 · 23 citations · 0 references
PharmacyMedicinal ChemistryDrug DiscoveryMycologyStructure-activity RelationshipsAntifungal AgentsAntifungal PharmacologyDisulfide Bond FormationFungal Secondary MetabolitesLead Compound DesignNatural Product-based Drug DesignFungal Drug DiscoveryNatural Antifungal CompoundsNew Antifungal AgentsNovel Antifungal Drug Development
From a design principle described in an earlier paper, a new series of substituted aryl methyl disulfides have been prepared and tested against Aspergillus niger and Aspergillus flavus . Methyl p -nitrophenyl disulfide is more potent (by an order of magnitude) than the fungitoxic natural product (CH3SCH2S)2. With the present rationale in hand, one can anticipate which Polycarpamine is an effective antifungal agent.