Gemcitabine-Induced Activation of Checkpoint Signaling Pathways That Affect Tumor Cell Survival

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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

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Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

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Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

Carrolee Barlow, Shinji Hirotsune, Richard Paylor et al. · Cell · 1996 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

Irene M. Ward, Junjie Chen · Journal of Biological Chemistry · 2001 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17